A survey of computational methods and error rate estimation procedures for peptide and protein identification in shotgun proteomics
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چکیده
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Integrating Genomic, Transcriptomic, and Interactome Data to Improve Peptide and Protein Identification in Shotgun Proteomics
Mass spectrometry (MS)-based shotgun proteomics is an effective technology for global proteome profiling. The ultimate goal is to assign tandem MS spectra to peptides and subsequently infer proteins and their abundance. In addition to database searching and protein assembly algorithms, computational approaches have been developed to integrate genomic, transcriptomic, and interactome information...
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ژورنال
عنوان ژورنال: Journal of Proteomics
سال: 2010
ISSN: 1874-3919
DOI: 10.1016/j.jprot.2010.08.009